Eligibility
Local study conflicts
- None
Inclusion Criteria: Must meet all of these:
- Aged 50yrs or over
- History or evidence of HI (for example: laceration; bruising; swelling or pain in head or face)
- GCS – 13, 14 or 15
- Has had one or more of:
- LOC &/or Amnesia &/or Confusion &/o Drowsy
- Nausea and/or Vomiting
- Within 3hrs of injury
Exclusion Criteria:
- Lives in nursing home, mental health institution or prison
- Over 3hrs since injury or time unknown
- TXA is clearly indicated due to other injuries, or contraindicated
If the patient is eligible:
Gain verbal agreement in principle before proceeding. Explain:
- Taking part in research is likely to improve the quality of their care
- Risks are carefully controlled - research is safe
- Explain the uncertainty that exists with respect to treatment of their condition;
- If they change their mind they can withdraw their participation at any point
Step-by-Step Guide to Recruitment:
In standard working hours; Mon-Fri 07:30-16:30
- Call the Trauma Hub on 07889 476009
Out of hours and weekends:
- Collect paperwork from the research box marked crash4 behind workstation in resus.
- Consent can be deferred if appropriate or relative can give consent (same consent form)
- Take next pack of drug (in numerical order) from the clinical trials cupboard in clean utility located next to resus.
- Prescribe on EPMA under clinical trials tab putting in the number from the drug pack. Anyone can give once prescribed.
- Place wristband from the drug pack on participant
- Entry form completed
- Document in participants notes.
- Place completed paperwork into the research box Crash4 for research nurse to collect.
Follow-up plan for discharged patients:
There is no formal follow up. The research nurse will check medical notes at 28days and will ring if participant has had any attendances at GP or ED